科尔顿血型系统：与基德（Jk）系统连锁的证据，支持其定位于7号染色体。

Colton blood groups: indication of linkage with the Kidd (Jk) system as support for assignment to chromosome 7.

作者信息

Mohr J, Eiberg H

出版信息

Clin Genet. 1977 May;11(5):372-4. doi: 10.1111/j.1399-0004.1977.tb01329.x.

DOI:10.1111/j.1399-0004.1977.tb01329.x

Abstract

A material of normal Danish families was tested for a number of genetic marker systems and analyzed for linkage. For the Colton-Kidd relationship the lod score was + 2.57. The Kidd system has earlier been tentatively assigned to chromosome 7 (Schokeir et al. 1973). The present data therefore permit a tentative assignment to chromosome 7 of the Colton system as well. The data also suggest that the discovery by Chapelle et al. (1975) of a conjunction of monosomy for chromosome 7 in the bone marrow of certain leukemia patients and absence of Colton antigen from the red cells may now be interpreted as being connected with location on chromosome 7 of the Colton system.

摘要

对一组丹麦正常家庭的材料进行了若干遗传标记系统的检测，并分析了连锁情况。对于科尔顿-基德关系，连锁值为+2.57。基德系统先前已初步定位到7号染色体（朔凯尔等人，1973年）。因此，目前的数据也允许将科尔顿系统初步定位到7号染色体。这些数据还表明，沙佩勒等人（1975年）在某些白血病患者的骨髓中发现7号染色体单体性与红细胞中缺乏科尔顿抗原的联合情况，现在可以解释为与科尔顿系统位于7号染色体上有关。