皮肤血管外坏死性肉芽肿（温克尔曼肉芽肿）：与全身性疾病关联的确认
Cutaneous extravascular necrotizing granuloma (Winkelmann granuloma): confirmation of the association with systemic disease.
作者信息
Wilmoth G J, Perniciaro C
机构信息
Department of Dermatology, Mayo Clinic Jacksonville, FL 32224, USA.
出版信息
J Am Acad Dermatol. 1996 May;34(5 Pt 1):753-9. doi: 10.1016/s0190-9622(96)90008-0.
BACKGROUND
An unusual palisading granuloma has been described in patients with immunoreactive diseases. Multiple names have been given to this lesion.
OBJECTIVE
Our aim was to verify whether a distinct palisading granuloma can be used as a marker for systemic disease. We also propose unifying nomenclature.
METHODS
Thirty-four biopsy specimens from 22 patients were selected for study on the basis of histologic criteria. The medical histories of these patients were subsequently reviewed for clinical information.
RESULTS
At least 21 of the 22 patients with cutaneous extravascular necrotizing granuloma had evidence of an underlying immunoreactive systemic illness. In each, the systemic disease preceded or was diagnosed concurrently with the cutaneous lesions.
CONCLUSION
The cutaneous extravascular necrotizing granuloma has unique clinical and histologic features. In a great majority of cases, a systemic immunoreactive disease is present.
背景
免疫反应性疾病患者中曾描述过一种不寻常的栅栏状肉芽肿。该病变有多个名称。
目的
我们的目的是验证一种独特的栅栏状肉芽肿是否可作为系统性疾病的标志物。我们还提议统一命名法。
方法
根据组织学标准，从22例患者中选取34份活检标本进行研究。随后回顾这些患者的病史以获取临床信息。
结果
22例皮肤血管外坏死性肉芽肿患者中至少21例有潜在免疫反应性全身性疾病的证据。在每例患者中，全身性疾病先于皮肤病变出现或与皮肤病变同时被诊断。
结论
皮肤血管外坏死性肉芽肿具有独特的临床和组织学特征。在绝大多数病例中，存在全身性免疫反应性疾病。
Zotero 插件