肺黏液性囊腺瘤
Mucinous cystadenoma of the lung.
作者信息
Roux F J, Lantuéjoul S, Brambilla E, Brambilla C
机构信息
Pulmonary Department, Centre Hospitalier Universitaire A. Michallon, La Tronche, France.
出版信息
Cancer. 1995 Nov 1;76(9):1540-4. doi: 10.1002/1097-0142(19951101)76:9<1540::aid-cncr2820760907>3.0.co;2-z.
BACKGROUND
Mucinous cystadenoma is an unusual pulmonary tumor that must be distinguished from mucinous cystic carcinoma and mucinous cystic tumors of borderline malignancy.
METHODS
This study of two cases was performed to characterize mucinous cystadenoma clinically and immunohistochemically, using proliferation markers (proliferating cell nuclear antigen [PCNA], MIB1) and carcinoembryonic antigen expression.
RESULTS
Pathologic examination in each instance showed unilocular cysts containing abundant clear mucus. The cysts were lined by tall mucinous epithelium, with absence of cytologic atypia and invasive growth. Proliferation markers using immunohistochemical methods showed less than 10% and 5% of labeled nuclei, respectively. Carcinoembryonic antigen immunostaining in both cases was negative. Patients remained free from recurrence for at least 2 years after surgery.
CONCLUSIONS
Mucinous cystadenoma of the lung appears to be a benign neoplasm because of its clinical course and immunohistochemical low expression of proliferation markers such as PCNA and MIB1.
背景
黏液性囊腺瘤是一种罕见的肺部肿瘤，必须与黏液性囊腺癌和交界性黏液性囊性肿瘤相鉴别。
方法
本研究对两例病例进行了临床和免疫组化特征分析，采用增殖标志物（增殖细胞核抗原[PCNA]、MIB1）和癌胚抗原表达情况进行研究。
结果
每例病例的病理检查均显示单房囊肿，内含大量清亮黏液。囊肿内衬高柱状黏液上皮，无细胞学异型性及浸润性生长。采用免疫组化方法检测增殖标志物，结果显示标记细胞核分别少于10%和5%。两例病例的癌胚抗原免疫染色均为阴性。患者术后至少2年无复发。
结论
肺黏液性囊腺瘤因其临床病程及PCNA和MIB1等增殖标志物的免疫组化低表达，似乎是一种良性肿瘤。
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