人类胶质瘤中10号染色体的缺失定位
Deletion mapping of chromosome 10 in human glioma.
作者信息
Sonoda Y, Murakami Y, Tominaga T, Kayama T, Yoshimoto T, Sekiya T
机构信息
Oncogene Division, National Cancer Center Research Institute, Tokyo, Japan.
出版信息
Jpn J Cancer Res. 1996 Apr;87(4):363-7. doi: 10.1111/j.1349-7006.1996.tb00231.x.
Abstract
We analyzed DNAs from 35 gliomas (27 malignant, grades III and IV; 8 less malignant, grades I and II) for loss of heterozygosity (LOH) using microsatellite sequences on chromosome 10 as polymorphic markers. An LOH was found in 8 of 11 (73%) glioblastomas (grade IV) and 4 of 16 (25%) grade III gliomas, but not in the less malignant types. We detected three commonly deleted regions. One was located in a telomeric region of 10p and the others were relatively large regions of 10q. Our results suggested that three putative tumor suppressor genes on chromosome 10 are involved in the malignant progression of gliomas.
摘要
我们使用10号染色体上的微卫星序列作为多态性标记，分析了35例神经胶质瘤（27例恶性，III级和IV级；8例低恶性，I级和II级）的DNA，以检测杂合性缺失（LOH）。在11例胶质母细胞瘤（IV级）中有8例（73%）和16例III级神经胶质瘤中有4例（25%）发现了LOH，但在低恶性类型中未发现。我们检测到三个常见的缺失区域。一个位于10p的端粒区域，其他两个是10q上相对较大的区域。我们的结果表明，10号染色体上的三个假定的肿瘤抑制基因参与了神经胶质瘤的恶性进展。
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本文引用的文献
1
Abnormalities of chromosome 22 in human brain tumors determined by combined cytogenetic and molecular genetic approaches.
Cancer Genet Cytogenet. 1993 Mar;66(1):1-10. doi: 10.1016/0165-4608(93)90140-h.
2
Gene and chromosomal alterations associated with the development of human gliomas.
FASEB J. 1993 Jul;7(10):926-30. doi: 10.1096/fasebj.7.10.8344489.
3
A cell cycle regulator potentially involved in genesis of many tumor types.
Science. 1994 Apr 15;264(5157):436-40. doi: 10.1126/science.8153634.
4
Analysis of the functional role of chromosome 10 loss in human glioblastomas.
Cancer Res. 1993 Oct 15;53(20):5043-50.
5
Deletion of p16 and p15 genes in brain tumors.
Cancer Res. 1994 Dec 15;54(24):6353-8.
6
Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25.
Oncogene. 1995 Jun 1;10(11):2243-6.
7
Loss of heterozygosity at 11p15 in malignant glioma.
Cancer Res. 1995 May 15;55(10):2166-8.
8
Deletion mapping of the long arm of chromosome 10 in glioblastoma multiforme.
Genes Chromosomes Cancer. 1993 Jul;7(3):173-7. doi: 10.1002/gcc.2870070311.
9
The 1993-94 Généthon human genetic linkage map.
Nat Genet. 1994 Jun;7(2 Spec No):246-339. doi: 10.1038/ng0694supp-246.
10
Two tumor suppressive loci on chromosome 10 involved in human glioblastomas.
Genes Chromosomes Cancer. 1995 Apr;12(4):255-61. doi: 10.1002/gcc.2870120404.
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