Yue N C, Benson M L
Russell H. Morgan Department of Radiology, Division of Neuroradiology, The Johns Hopkins Medical Institutions, 600 N. Wolfe Street, Baltimore, MD 21287-2182, USA.
Pediatr Radiol. 1996;26(6):421-3. doi: 10.1007/BF01387319.
We report a case illustrating characteristic facial deformities following irradiation during infancy for bilateral retinoblastoma. CT and MR imaging revealed distinctive features of the resulting "hourglass facial deformity": hypotelorism, enophthalmos, depressed temporal bones, atrophy of the temporalis muscles, and a depressed nasion. This case also displayed premature metopic craniosynostosis and frontal sinus aplasia; these may be additional hallmarks of this deformity.
