Hoffstetter S, Malissard L, N'Guyen T D, Panis X, Jung G M, Bachaud J M, Prevost B, Quint R, Chaplain G, Eschwège F, Rambert P, Fleury-Touzeau F
Centre Alexis-Vautrin, Vandoeuvre-lès-Nancy, France.
Bull Cancer Radiother. 1996;83(2):86-9.
From 1981 to 1985, 428 patients presenting with an epidermoid carcinoma of the hypopharynx and/or larynx were treated with a curative intent by surgical resection and postoperative irradiation. Two-thirds of the tumours were T3 and 60% of patients presented with a clinical node involvement. The rates of local failure were 8%, 18% and 13%, respectively, for cancers of the larynx, of the piriform sinus and of the posterior wall; the rates of regional failure were 8%, 23% and 13%, respectively. There is no head and neck site with either a high or low risk of recurrence after resection, but the capsular rupture remains a factor of poor prognosis. The survival rate at 5 years of the whole series is 38%, for laryngeal localisation it reaches 62%. The risk of metastases is related to the node involvement and the interval between surgery and irradiation.
1981年至1985年期间,428例下咽和/或喉表皮样癌患者接受了旨在治愈的手术切除及术后放疗。三分之二的肿瘤为T3期,60%的患者有临床淋巴结受累。喉癌、梨状窦癌和后壁癌的局部失败率分别为8%、18%和13%;区域失败率分别为8%、23%和13%。切除术后没有任何头颈部部位具有高或低复发风险,但包膜破裂仍是预后不良的一个因素。整个系列的5年生存率为38%,喉部定位的5年生存率达到62%。转移风险与淋巴结受累情况以及手术与放疗之间的间隔有关。