Montanini I, Castigli E, Arienti U G, Porcellati G
Farmaco Sci. 1977 Feb;32(2):141-6.
Female Wistar rats have been injected intravenously for seven days with various different doses of silybin, the main component of the drug silymarin, and the in vitro synthesis of phosphatidylethanolamine and phosphatidylcholine from their respective precursors, CDP-ethanolamine and CDP-choline has been examined in liver microsomal membranes. Appreciable inhibition of the incorporation rates of precursors into lipids has been noticed at dosage of 15-20 mg/100 g body wt., daily. No evident effect is exerted by similar silybin treatment on choline and ethanolamine incorporation respectively into liver phosphatidylcholine and phosphatidylethanolamine in vivo.
给雌性Wistar大鼠静脉注射不同剂量的水飞蓟宾(药物水飞蓟素的主要成分),持续七天,然后检测肝微粒体膜中从各自前体CDP - 乙醇胺和CDP - 胆碱体外合成磷脂酰乙醇胺和磷脂酰胆碱的情况。每天以15 - 20毫克/100克体重的剂量给药时,已注意到前体掺入脂质的速率受到明显抑制。类似的水飞蓟宾处理对体内胆碱和乙醇胺分别掺入肝磷脂酰胆碱和磷脂酰乙醇胺没有明显影响。