新生儿血液中CD4⁺和CD8⁺T细胞亚群以及CD45RA（低）CD45RO（低）T细胞亚群上CD45异构体的定量表达不足。
Deficient quantitative expression of CD45 isoforms on CD4+ and CD8+ T cell subpopulations and subsets of CD45RA(low)CD45RO(low) T cells in newborn blood.
作者信息
Chheda S, Palkowetz K H, Rassin D K, Goldman A S
机构信息
Department of Pediatrics, University of Texas Medical Branch, Galveston 77555-0526, USA.
出版信息
Biol Neonate. 1996;69(2):128-32. doi: 10.1159/000244287.
Deficiencies in the quantitative expression of CD45RA and CD45RO on CD4+ and CD8+ T cells and in a population of CD45RA(low)CD45RO(low) T cells in blood from term newborn infants were found by flow cytometry. The relative frequencies of CD45RO on CD4+ T cells from adults and newborn infants were 72 and 58%, respectively. However, in newborn infants greater than 70% of T cells expressing CD45RO also expressed CD45RA. In addition, the quantitative expression of CD45RA and CD45RO on newborn T cells was significantly less than that found on adult blood T cells.
通过流式细胞术发现，足月新生儿血液中CD4⁺和CD8⁺T细胞上CD45RA和CD45RO的定量表达以及一群CD45RA（低）CD45RO（低）T细胞存在缺陷。成人和新生儿CD4⁺T细胞上CD45RO的相对频率分别为72%和58%。然而，在新生儿中，表达CD45RO的T细胞中有超过70%也表达CD45RA。此外，新生儿T细胞上CD45RA和CD45RO的定量表达明显低于成人血液T细胞。
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