Meseguer García P, Gonzalvo Pérez V, Botella Almodovar R, Escandón Alvarez J, Gómez Castro A, Polo Peris A C
Servicio de Urología, Hospital Lluis Alcanyis de Xativa, Valencia.
Actas Urol Esp. 1996 Jan;20(1):63-7.
One case of transitional cells carcinoma with sarcomatoid pattern, located in the renal pelvis in a 77 year-old male with haematuria. The tumour also expressed a non-neoplastic component of osteoclast-like giant cells which probably represent a stromal reaction of the host to the neoplasia. The tumoral cells co-express keratin and vimentin, two strands of the cytoskeleton specific for epithelial and mesenchymal cells, respectively. We speculate with the possibility of the tumoral cells fusocellular morphology being related to the vimentin expression. A review of the literature is also included.
1例具有肉瘤样形态的移行细胞癌,位于一名77岁血尿男性的肾盂。肿瘤还表现出破骨细胞样巨细胞这一非肿瘤成分,其可能代表宿主对肿瘤形成的间质反应。肿瘤细胞共表达角蛋白和波形蛋白,这两条细胞骨架链分别特异性地存在于上皮细胞和间充质细胞中。我们推测肿瘤细胞的梭形细胞形态可能与波形蛋白表达有关。本文还包括文献综述。