Jacquet P, Elias D, Sugarbaker P H
Washington Cancer Institute, Washington, DC 20010, USA.
J Chir (Paris). 1996 Jun;133(4):175-82.
The natural history of surgically treated intraabdominal malignancy is such that a large proportion of patients present tumor recurrence at wound sites. Numerous factors operating within the wound environment are important determinants in tumor cells arrest or growth at these sites. This article describes the interactions between the traumatized tissues and tumor cells, and attempts to understand the important factors that may have an impact on implantation of cancer cells in wound sites. Modifications of these biologic factors may represent new perspectives for preventing tumor recurrence in intraabdominal wound sites.
接受手术治疗的腹内恶性肿瘤的自然病程是,很大一部分患者会在伤口部位出现肿瘤复发。伤口环境中起作用的众多因素是肿瘤细胞在这些部位停滞或生长的重要决定因素。本文描述了受创组织与肿瘤细胞之间的相互作用,并试图了解可能影响癌细胞在伤口部位植入的重要因素。对这些生物学因素的调节可能为预防腹内伤口部位的肿瘤复发提供新的思路。