与菌血症患者高死亡率相关的耐甲氧西林金黄色葡萄球菌类型。

Types of methicillin-resistant Staphylococcus aureus associated with high mortality in patients with bacteremia.

作者信息

Nada T, Ichiyama S, Iinuma Y, Inuzuka K, Washida H, Ohta M, Shimokata K, Kato N, Nakashima N

机构信息

Department of Clinical Laboratory Medicine, Nagoya University Hospital, Japan.

出版信息

Eur J Clin Microbiol Infect Dis. 1996 Apr;15(4):340-3. doi: 10.1007/BF01695669.

DOI:10.1007/BF01695669

PMID:8781888

Abstract

Forty-seven strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated from 47 patients with bacteremia were analyzed by chromosomal DNA digestion pattern using pulsed-field gel electrophoresis and evaluated for serological coagulase type, enterotoxin type, and toxic shock syndrome toxin-1 production. The mortality rate was significantly higher in the older patients (> or = 51 years of age) than in the younger patients (< or = 50 years of age) (50% vs. 4%, p = 0.0007). Methicillin-resistant Staphylococcus aureus strains of serological coagulase type II were more likely to be associated with mortality in older patients than were strains of the other types (p = 0.037).

摘要

采用脉冲场凝胶电泳法，通过染色体DNA消化模式对从47例菌血症患者中分离出的47株耐甲氧西林金黄色葡萄球菌（MRSA）进行分析，并对其血清凝固酶类型、肠毒素类型和毒性休克综合征毒素-1产生情况进行评估。老年患者（年龄≥51岁）的死亡率显著高于年轻患者（年龄≤50岁）（50%对4%，p = 0.0007）。血清凝固酶II型的耐甲氧西林金黄色葡萄球菌菌株比其他类型的菌株更易与老年患者的死亡相关（p = 0.037）。