Tollis M, Di Trani L, Cordioli P, Vignolo E, Di Pasquale I
Istituto Superiore di Sanità, Rome, Italy.
Dev Biol Stand. 1996;86:147-56.
The Istituto Superiore di Sanità (ISS), the National Veterinary Services Laboratory in Italy, is in charge of assessing the quality, safety and efficacy of veterinary vaccines before and after licensing. To evaluate the relative potency of several vaccines against bovine respiratory syncytial virus (BRSV), infectious bovine rhinotracheitis virus (IBRV), bovine viral diarrhoea virus (BVDV) and parainfluenza-3 virus (PI3V), the serological responses in vaccinated calves were studied. Vaccination with any of the vaccines under study induced specific antibody titres against the different viral antigens. The differences of the mean antibody titres within and among the test group vaccines were statistically significant. The results confirm and support those obtained by other authors in similar studies, suggesting that serological responses in vaccinated calves can be used as a helpful means of assessing the relative potency of vaccines against viral respiratory diseases of cattle. The criteria allowing such an evaluation are discussed.
意大利高等卫生研究院（ISS），即意大利国家兽医服务实验室，负责在兽用疫苗许可前后评估其质量、安全性和有效性。为评估几种疫苗针对牛呼吸道合胞病毒（BRSV）、传染性牛鼻气管炎病毒（IBRV）、牛病毒性腹泻病毒（BVDV）和副流感3型病毒（PI3V）的相对效力，研究了接种疫苗的犊牛的血清学反应。用所研究的任何一种疫苗进行接种均诱导了针对不同病毒抗原的特异性抗体滴度。试验组疫苗内部和之间的平均抗体滴度差异具有统计学意义。结果证实并支持了其他作者在类似研究中获得的结果，表明接种疫苗的犊牛的血清学反应可作为评估疫苗针对牛病毒性呼吸道疾病相对效力的有用手段。讨论了允许进行这种评估的标准。
