Atwood L D, Mitchell B D, Stowell N C
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78228-0147, USA.
Genet Epidemiol. 1995;12(6):713-8. doi: 10.1002/gepi.1370120630.
Segregation and linkage analysis of GAW9 Problem 2 quantitative trait 1 (Q1) was performed. Eight segregation models comprising all possible combinations of the environmental factor (EF), quantitative trait 2 (Q2), and quantitative trait 3 (Q3) as covariates were considered. Seven of the eight segregation models showed strong evidence for a major gene, the other model was marginal. When all genotypes are known, some evidence for linkage (lod > 2) was found to all three of the markers that affect Q1. Furthermore, four of the eight models each showed some linkage (lod > 2) to two of the three markers that affect Q1 with no false positives. Each of these segregation analysis major genes is a hybrid combination of the true multiple loci that affect Q1.
对GAW9问题2的数量性状1(Q1)进行了分离和连锁分析。考虑了八个分离模型,这些模型包含环境因素(EF)、数量性状2(Q2)和数量性状3(Q3)作为协变量的所有可能组合。八个分离模型中的七个显示出存在主基因的有力证据,另一个模型证据不明显。当所有基因型已知时,发现影响Q1的所有三个标记都有一些连锁证据(lod>2)。此外,八个模型中的四个模型各自显示出与影响Q1的三个标记中的两个有一些连锁(lod>2),且无假阳性。这些分离分析中的每个主基因都是影响Q1的真正多个基因座的混合组合。