Pethig K, Schäfers H J, Borst H G
Division of Thoracic and Cardiovascular Surgery, Surgical Center, Hannover Medical School, Germany.
J Heart Valve Dis. 1996 May;5(3):247-50.
Aortic insufficiency due to dilation of the aortic root is a common finding. Although combined replacement of the aortic valve and the ascending aorta is regarded as standard treatment, total replacement of the proximal aorta with a tube graft and resuspension of the valve is a new alternative.
Between June 1993 and June 1995, 23 patients underwent this type of aortic repair. Seven patients exhibited the typical features of Marfan's syndrome. Echocardiography was performed pre- and intraoperatively as well as three, six and then every 12 months postoperatively for a cumulative follow up period of 355 months (5-30; mean 15.9 +/- 7.9 months).
The pre-existing aortic valve insufficiency (grade II-IV, mean 2.9) was reduced postoperatively to grade 0-1 (mean 0.3). The NYHA functional class improved from a mean of 2.8 to 1.8. During the follow up period 20 patients showed a stable valve function with either no (n = 13), or a mild valve regurgitation (n = 7). Two patients had to be reoperated for progressive aortic insufficiency 11 and 14 months after repair, undergoing valve replacement. A third patient required reoperation because of relapsing endocarditis.
It is concluded that in patients with aortic valve insufficiency due to dilation of the proximal aorta, valve sparing reconstruction is a promising approach. Without the need for anticoagulation, good functional results could be demonstrated. Further follow up is required to assess the long term function of this kind of aortic valve repair.
主动脉根部扩张所致主动脉瓣关闭不全是常见病症。尽管主动脉瓣与升主动脉联合置换被视为标准治疗方法,但用人工血管置换主动脉近端并重新悬吊瓣膜是一种新的选择。
1993年6月至1995年6月,23例患者接受了此类主动脉修复手术。7例患者表现出典型的马凡综合征特征。术前、术中以及术后3个月、6个月,随后每12个月进行超声心动图检查,累计随访期为355个月(5 - 30个月;平均15.9±7.9个月)。
术前存在的主动脉瓣关闭不全(II - IV级,平均2.9级)术后降至0 - 1级(平均0.3级)。纽约心脏协会(NYHA)心功能分级从平均2.8级改善至1.8级。在随访期内,20例患者瓣膜功能稳定,其中13例无瓣膜反流,7例有轻度瓣膜反流。2例患者在修复术后11个月和14个月因进行性主动脉瓣关闭不全需再次手术,接受瓣膜置换。第3例患者因复发性心内膜炎需要再次手术。
得出结论,对于因主动脉近端扩张导致主动脉瓣关闭不全的患者,保留瓣膜的重建术是一种有前景的方法。无需抗凝治疗,可获得良好的功能结果。需要进一步随访以评估此类主动脉瓣修复的长期功能。