Masanés F, Pedrol E, Grau J M, Coll-Vinent B, Casademont J, Miró O, Mallolas J, Urbano-Márquez A
Service of Internal Medicine, Hospital Clínic i Provincial, University of Barcelona, Spain.
Clin Neuropathol. 1996 Jul-Aug;15(4):221-5.
To assess the clinico-pathological profile of symptomatic myopathies developing in HIV-1 infected patients before use of any antiretroviral therapy.
Prospective, cross-sectional study.
University-referral, tertiary care Hospital.
Thirty consecutively admitted, HIV-1 infected patients untreated with antiretrovirals and with clinically suspected skeletal myopathy or raised serum creatinkinase levels.
Clinical assessment of muscle strength and open muscle biopsy regarding to histopathological features.
Most of the HIV-1 infected patients were weaker when compared to the matched healthy control group. Only a few patients presented with myalgia. In one third of the cases an inflammatory condition (microvasculitis, myositis) was evident. In another third minor myopathic changes were observed, while in the remaining cases muscle biopsy was normal. Abnormal values of CK correlated poorly with pathologic diagnosis.
In a significant proportion of HIV-1 infected symptomatic patients a specific treatment can be given when the existence of an inflammatory condition is diagnosed by muscle biopsy.
评估在使用任何抗逆转录病毒疗法之前，HIV-1感染患者出现的有症状性肌病的临床病理特征。
前瞻性横断面研究。
大学转诊的三级护理医院。
30例连续入院的未接受抗逆转录病毒治疗、临床怀疑患有骨骼肌病或血清肌酸激酶水平升高的HIV-1感染患者。
对肌肉力量进行临床评估，并进行开放性肌肉活检以观察组织病理学特征。
与匹配的健康对照组相比，大多数HIV-1感染患者的肌肉力量较弱。只有少数患者出现肌痛。三分之一的病例有炎症情况（微血管炎、肌炎）明显。另有三分之一观察到轻微的肌病变化，而其余病例肌肉活检正常。肌酸激酶的异常值与病理诊断相关性较差。
在相当一部分有症状的HIV-1感染患者中，当通过肌肉活检诊断出存在炎症情况时，可以给予特定治疗。
