奈替米星的药代动力学研究。
Pharmacokinetic study of netilmicin.
作者信息
Meyers B R, Hirschman S Z, Wormser G, Siegel D
出版信息
Antimicrob Agents Chemother. 1977 Jul;12(1):122-3. doi: 10.1128/AAC.12.1.122.
Abstract
Netilmicin at a dose of 2 mg/kg was infused intravenously into 10 healthy volunteers. A peak serum concentration of 16.56 mug/ml was obtained at the end of the infusion. Thirty-nine percent of the infused dose was excreted in the urine during the first 8 h after infusion. The pharmacokinetic parameters of netilmicin were derived by analyzing the elimination data according to a two-compartment model.
摘要
将剂量为2毫克/千克的奈替米星静脉输注给10名健康志愿者。输注结束时血清峰值浓度为16.56微克/毫升。输注后最初8小时内，39%的输注剂量经尿液排出。根据二室模型分析消除数据得出奈替米星的药代动力学参数。
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