Arena A, Capozza A B, Di Luca D
Institute of Microbiology, University of Messina, Italy.
New Microbiol. 1996 Jul;19(3):183-91.
The release of monokines such as Tumor Necrosis Factor a (TNF alpha), Interleukin-1 beta (IL-1 beta) and Interleukin-6 (IL-6) by activated monocytes/macrophages is an important step in the immune as well as in the inflammatory response. In this study the production of TNF alpha, IL-1 beta and IL-6 by human monocytes (HM) and peripheral blood mononuclear cells (PBMC) was evaluated after HHV-6 infection. Our results demonstrate that HHV-6 can selectively regulate monokine synthesis, in a time-dependent manner. Moreover, we observed a different response closely related to the cellular population (HM or PBMC) examined. The hypothesis we evaluated was that IFN gamma is an important factor triggering the activation of HHV-6 infected human monocytes, to release monokines.
活化的单核细胞/巨噬细胞释放诸如肿瘤坏死因子α（TNFα）、白细胞介素-1β（IL-1β）和白细胞介素-6（IL-6）等单核因子是免疫反应以及炎症反应中的重要一步。在本研究中，评估了人单核细胞（HM）和外周血单核细胞（PBMC）在HHV-6感染后TNFα、IL-1β和IL-6的产生情况。我们的结果表明，HHV-6能够以时间依赖性方式选择性地调节单核因子的合成。此外，我们观察到与所检测的细胞群体（HM或PBMC）密切相关的不同反应。我们评估的假设是，干扰素γ是触发HHV-6感染的人单核细胞活化以释放单核因子的重要因素。
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