[A study of relation between pulmonary function and bronchial hypersensitivity in severe asthmatic children].

We studied 198 acetylcholine inhalation tests in 31 subjects and 260 exercise loading tests in 43 subjects, who were severe asthmatic children received institutional therapy. Respiratory threshold to acetylcholine (RT-Ach) were significantly lower when %V50 or %MMF were less than 60%. %V50 were significantly lower when EIB (maximum %fall in FEV1.0 after exercise) were more than 15%. These results suggest that in bronchial hypersensitivity tests, %V50 and %MMF which are indexes of peripheral airway obstruction should be examined.