尿素作为精氨琥珀酸裂解酶的选择性抑制剂。
Urea as a selective inhibitor of argininosuccinate lyase.
作者信息
Menyhárt J, Gróf J
出版信息
Eur J Biochem. 1977 May 16;75(2):405-9. doi: 10.1111/j.1432-1033.1977.tb11541.x.
Abstract
The effect of urea on various ornithine cycle enzymes has been investigated. It was demonstrated that argininosuccinate lyase was the only ornithine cycle enzyme inhibited by urea in a competitive manner. Based on the data presented the possible role of urea in maintaining a physiological range of intracellular and extracellular urea concentration by controlling hepatic ureogenesis was discussed.
摘要
已对尿素对各种鸟氨酸循环酶的作用进行了研究。结果表明，精氨琥珀酸裂解酶是唯一一种受尿素竞争性抑制的鸟氨酸循环酶。根据所提供的数据，讨论了尿素通过控制肝脏尿素生成在维持细胞内和细胞外尿素浓度生理范围内的可能作用。
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