甲氨蝶呤治疗儿童韦格纳肉芽肿病

Methotrexate treatment of Wegener granulomatosis in children.

作者信息

Gottlieb B S, Miller L C, Ilowite N T

机构信息

Department of Pediatrics, Schneider Children's Hospital, Long Island Jewish Medical Center, New Hyde Park, New York, USA.

出版信息

J Pediatr. 1996 Oct;129(4):604-7. doi: 10.1016/s0022-3476(96)70128-2.

DOI:10.1016/s0022-3476(96)70128-2

PMID:8859270

Abstract

Wegener granulomatosis traditionally has been treated with glucocorticoids and cyclophosphamide. Both the disease and its treatments are associated with significant morbidity and mortality rates. There has been an effort to find effective but less toxic alternative treatments. We describe three children with Wegener granulomatosis who responded well to treatment with glucocorticoids and methotrexate, similar to a regimen used in adults.

摘要

传统上，韦格纳肉芽肿病采用糖皮质激素和环磷酰胺进行治疗。该疾病及其治疗方法均与显著的发病率和死亡率相关。人们一直在努力寻找有效但毒性较小的替代治疗方法。我们描述了三名患有韦格纳肉芽肿病的儿童，他们对糖皮质激素和甲氨蝶呤联合治疗反应良好，这与成人使用的治疗方案类似。