Cisplatin and etoposide chemotherapy in the treatment of adult Wilms' tumor.

A 64-year-old man underwent left radical nephrectomy for stage III anaplastic Wilms' tumor. He received adjuvant chemotherapy consisting of cisplatin and etoposide. Complete clinical response was achieved and maintained for 12 months. A systemic relapse after 1 year also responded to three more cycles of cisplatin and etoposide. Although cisplatin- and etoposide-based chemotherapy was not used as a first-line therapy in adult patients with Wilms' tumor described in the literature, this case demonstrates the promising activity of this combination also in adults with this disease entity.