光卟啉Ⅱ与准分子染料激光光动力疗法治疗早期胃癌的合作临床试验。
Cooperative clinical trial of photodynamic therapy with photofrin II and excimer dye laser for early gastric cancer.
作者信息
Mimura S, Ito Y, Nagayo T, Ichii M, Kato H, Sakai H, Goto K, Noguchi Y, Tanimura H, Nagai Y, Suzuki S, Hiki Y, Hayata Y
机构信息
Department of Gastroenterology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.
出版信息
Lasers Surg Med. 1996;19(2):168-72. doi: 10.1002/(SICI)1096-9101(1996)19:2<168::AID-LSM7>3.0.CO;2-Q.
BACKGROUND AND OBJECTIVE
Photodynamic therapy (PDT) is a recently developed endoscopic method for treating malignant tumors. For obtaining more photodynamic action with less thermal effect, we employed as the excitation light source for PDT an excimer dye laser, which is a pulsed laser with extremely high peak power, instead of an argon dye laser, which is a continuous wave laser and has been used conventionally.
STUDY DESIGN/MATERIALS AND METHODS: The effect of PDT using Photofrin II and the excimer dye laser was evaluated in 27 patients with early gastric cancer.
RESULTS
Complete responses (CR) were obtained in 88% of 24 assessable patients and the response rate was 100%. CR was observed in all cases of lesions of superficial depressed type without ulceration and/or with tumor diameter less than 2 cm. Regarding toxicity, mild cutaneous reaction and photosensitivity were seen and lasted several weeks. There were no serious abnormalities in laboratory tests.
CONCLUSION
We conclude that PDT is a promising modality for early gastric cancer.
背景与目的
光动力疗法（PDT）是一种最近开发的用于治疗恶性肿瘤的内镜方法。为了在产生较少热效应的情况下获得更强的光动力作用，我们使用准分子染料激光作为光动力疗法的激发光源，它是一种具有极高峰值功率的脉冲激光，而不是传统上使用的连续波氩染料激光。
研究设计/材料与方法：对27例早期胃癌患者评估了使用光敏剂Ⅱ和准分子染料激光进行光动力疗法的效果。
结果
24例可评估患者中有88%获得完全缓解（CR），缓解率为100%。在所有浅表凹陷型无溃疡和/或肿瘤直径小于2 cm的病变病例中均观察到CR。关于毒性，出现了轻度皮肤反应和光敏反应，持续数周。实验室检查未发现严重异常。
结论
我们得出结论，光动力疗法是早期胃癌一种很有前景的治疗方式。
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