Dassa D, Sham P C, van Os J, Abel K, Jones P, Murray R M
Département de Psychiatrie, C.H.U. Timone, Marseille, France.
Psychiatry Res. 1996 Aug 30;64(1):11-7. doi: 10.1016/0165-1781(96)02868-5.
Birth in late winter and spring has been consistently shown to be a risk factor of schizophrenia. The relationship of late winter/spring birth to clinical characteristics and other putative risk factors, such as family history and obstetric complications, may provide clues to etiology. Data relating to season of birth, clinical features, family history, and obstetric complications were analyzed for 192 patients with schizophrenia as defined by Research Diagnostic Criteria (including schizoaffective disorder). There was no significant association of season of birth with any of the psychopathological dimensions nor was there a significant association with obstetric variables or family history. However, winter-born schizophrenic patients who had a negative family history were more likely to have a history of obstetric complications. These findings suggest that obstetric complications associated with schizophrenia are perhaps the result of some seasonal risk factors important in those without a family history of the disorder.
一直以来，出生在冬末和春季被证明是精神分裂症的一个风险因素。冬末/春季出生与临床特征以及其他假定风险因素（如家族病史和产科并发症）之间的关系，可能为病因学提供线索。对192例根据研究诊断标准（包括分裂情感性障碍）确诊为精神分裂症的患者，分析了其出生季节、临床特征、家族病史和产科并发症的数据。出生季节与任何精神病理学维度均无显著关联，与产科变量或家族病史也无显著关联。然而，家族病史为阴性的冬季出生的精神分裂症患者更有可能有产科并发症史。这些发现表明，与精神分裂症相关的产科并发症可能是某些季节性风险因素的结果，这些因素对无该疾病家族病史的人很重要。
