菊科植物花中二羟基和三羟基三萜对12-O-十四酰佛波醇-13-乙酸酯诱导的小鼠炎症的抑制作用

Inhibitory effect of Di- and trihydroxy triterpenes from the flowers of compositae on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice.

作者信息

Yasukawa K, Akihisa T, Oinuma H, Kasahara Y, Kimura Y, Yamanouchi S, Kumaki K, Tamura T, Takido M

机构信息

College of Pharmacy, Nihon University, Chiba, Japan.

出版信息

Biol Pharm Bull. 1996 Oct;19(10):1329-31. doi: 10.1248/bpb.19.1329.

DOI:10.1248/bpb.19.1329

PMID:8913506

Abstract

Ten dihydroxy- and trihydroxy triterpenes, viz., four taraxastanes: faradiol, heliantriol B0, heliantriol C and arnidiol; two lupanes: calenduladiol and heliantriol B2; two oleananes: maniladiol and longispinogenin; and two ursanes: brein and uvaol, isolated from the nonsaponifiable lipids of the flower extracts of Compositae plants were evaluated with respect to their anti-inflammatory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. All the triterpenes were found to possess marked inhibitory activity. The 50% inhibitory dose of these compounds with respect to TPA-inflammation (1 microgram) was 0.03-0.2 mg/ear.

摘要

从菊科植物花提取物的不皂化脂质中分离出10种二羟基和三羟基三萜，即4种蒲公英甾烷：法呢二醇、向日葵三醇B0、向日葵三醇C和arnidiol；2种羽扇豆烷：金盏二醇和向日葵三醇B2；2种齐墩果烷：马尼拉二醇和长棘皂苷元；以及2种乌苏烷：布瑞因和uvaol，评估了它们对12-O-十四酰佛波醇-13-乙酸酯（TPA）诱导的小鼠炎症的抗炎活性。发现所有三萜均具有显著的抑制活性。这些化合物对TPA炎症（1微克）的50%抑制剂量为0.03-0.2毫克/耳。