一窝加拉菲阿诺牧羊犬中的胶原蛋白发育异常。
Collagen dysplasia in a litter of Garafiano shepherd dogs.
作者信息
Rodriguez F, Herráez P, Espinosa de los Monteros A, Calabuig P, Rodríguez J L
机构信息
Department of Histology and Pathological Anatomy, Veterinary Faculty, University of Las Palmas de Gran Canaria, Spain.
出版信息
Zentralbl Veterinarmed A. 1996 Oct;43(8):509-12. doi: 10.1111/j.1439-0442.1996.tb00482.x.
A connective tissue disease resembling the human Ehlers-Danlos syndrome is reported in three Garafiano shepherd dogs from the same litter. The clinical signs included skin hyperextensibility and fragility, joint laxity, and ocular lesions. Microscopical studies showed abnormalities in the packing of collagen in fibrils and fibres in the skin. Systemic connective tissue defects were demonstrated in one necropsied puppy.
据报道，同一窝的三只加拉菲阿诺牧羊犬患有一种类似于人类埃勒斯-丹洛斯综合征的结缔组织疾病。临床症状包括皮肤过度伸展和脆弱、关节松弛以及眼部病变。显微镜研究显示，皮肤中胶原纤维和纤维的排列存在异常。在一只进行了尸检的幼犬中发现了全身性结缔组织缺陷。
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