人类白细胞抗原-DQ分子的多态性氨基酸结构域与重症肌无力的疾病异质性相关。

Polymorphic amino acid domains of the HLA-DQ molecule are associated with disease heterogeneity in myasthenia gravis.

作者信息

Hjelmström P, Giscombe R, Lefvert A K, Pirskanen R, Kockum I, Landin-Olsson M, Sanjeevi C B

机构信息

Department of Molecular Medicine, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden.

出版信息

J Neuroimmunol. 1996 Apr;65(2):125-31. doi: 10.1016/0165-5728(96)00008-2.

DOI:10.1016/0165-5728(96)00008-2

PMID:8964894

Abstract

The association between myasthenia gravis (MG) and polymorphic amino acid domains in the HLA-DQ molecule was studied in 79 Swedish patients and 155 unrelated, population-based controls. A domain unique for DQB10201 was positively associated in MG patients with thymic hyperplasia or an early disease onset, and two domains with residues common to DQA101 alleles or DQB105 and DQB106 alleles were negatively associated in patients with thymic hyperplasia or an early disease onset. Our results suggest that MG associated with thymic hyperplasia and thymoma differ in their HLA-DQ association and thus are likely to have different pathogenic mechanisms.

摘要

在79名瑞典患者和155名无关的、基于人群的对照中，研究了重症肌无力（MG）与HLA - DQ分子中多态性氨基酸结构域之间的关联。DQB10201特有的一个结构域在伴有胸腺增生或疾病早期发作的MG患者中呈正相关，而两个分别具有DQA101等位基因或DQB105和DQB106等位基因共有的残基的结构域，在伴有胸腺增生或疾病早期发作的患者中呈负相关。我们的结果表明，与胸腺增生和胸腺瘤相关的MG在HLA - DQ关联方面存在差异，因此可能具有不同的致病机制。