酮色林治疗鱼精蛋白诱导的肺动脉高压。
Ketanserin in the treatment of protamine-induced pulmonary hypertension.
作者信息
van der Starre P J, Solinas C
机构信息
Department of Cardiothoracic Anesthesiology and Intensive Care Hospital De Weezenlanden, Netherlands.
出版信息
Tex Heart Inst J. 1996;23(4):301-4.
Abstract
The reversal of heparin by protamine may cause severe hemodynamic deterioration, characterized by systemic hypotension, pulmonary hypertension, and bronchoconstriction. A case report is presented concerning the administration of ketanserin in the treatment of pulmonary vasoconstriction and right ventricular failure following the infusion of protamine in a patient undergoing coronary artery bypass surgery and mitral valve replacement. The potential role of serotonin in the development of this serious complication is discussed.
摘要
鱼精蛋白逆转肝素作用可能会导致严重的血流动力学恶化，其特征为全身性低血压、肺动脉高压和支气管收缩。本文报告了1例在接受冠状动脉搭桥手术和二尖瓣置换术的患者输注鱼精蛋白后，使用酮色林治疗肺血管收缩和右心室衰竭的病例。文中讨论了5-羟色胺在这一严重并发症发生过程中的潜在作用。
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Role of serotonin in the pathogenesis of acute and chronic pulmonary hypertension.血清素在急慢性肺动脉高压发病机制中的作用
Thorax. 1999 Feb;54(2):161-8. doi: 10.1136/thx.54.2.161.
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