1例具有软骨分化的黏液样脂肪肉瘤的细胞遗传学分析
Cytogenetic analysis of a case of myxoid liposarcoma with cartilaginous differentiation.
作者信息
Dijkhuizen T, Molenaar W M, Hoekstra H J, Wiersema J, van den Berg E
机构信息
Department of Medical Genetics, Groningen University, The Netherlands.
出版信息
Cancer Genet Cytogenet. 1996 Dec;92(2):141-3. doi: 10.1016/s0165-4608(96)00184-7.
The cytogenetic analysis of a patient with a myxoid liposarcoma exhibiting cartilaginous differentiation is presented. A complex translocation involving chromosome 12, 16, and 19 was found, instead of the t(12;16), specific for myxoid liposarcoma. The involvement of 19q13 in a tumor with cartilaginous differentiation, and the assignment of TGF beta 1 to 19q13.1-13.2, which appears to play a role in the formation of bone and cartilage, suggest a possible relation between both.
本文呈现了一例表现出软骨分化的黏液样脂肪肉瘤患者的细胞遗传学分析。发现了涉及12号、16号和19号染色体的复杂易位，而不是黏液样脂肪肉瘤特有的t(12;16)。19q13参与了具有软骨分化的肿瘤，且TGFβ1定位于19q13.1 - 13.2，这似乎在骨和软骨形成中发挥作用，提示两者之间可能存在关联。
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