染色体畸变的诱导机制及其荧光原位杂交检测
Mechanisms of induction of chromosomal aberrations and their detection by fluorescence in situ hybridization.
作者信息
Natarajan A T, Balajee A S, Boei J J, Darroudi F, Dominguez I, Hande M P, Meijers M, Slijepcevic P, Vermeulen S, Xiao Y
机构信息
MGC Department of Radiation Genetics and Chemical Mutagenesis, Leiden University, The Netherlands.
出版信息
Mutat Res. 1996 Dec;372(2):247-58. doi: 10.1016/s0027-5107(96)00144-3.
PMID:9015143
Abstract
Fluorescence in situ hybridization (FISH) technique using chromosome specific probes has revolutionized the field of radiation cytogenetics in the last few years. Some of the new insights on the origins of radiation induced chromosome aberrations in human, mouse and Chinese hamster, using FISH are reviewed in this paper.
摘要
在过去几年中，使用染色体特异性探针的荧光原位杂交（FISH）技术彻底改变了辐射细胞遗传学领域。本文综述了利用FISH技术在人类、小鼠和中国仓鼠中对辐射诱导染色体畸变起源的一些新见解。
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