Hanna E Z, Chou S P, Grant B F
National Institute on Alcohol Abuse and Alcoholism, Division of Biometry and Epidemiology, Bethesda, Maryland 20892-7003, USA.
Alcohol Clin Exp Res. 1997 Feb;21(1):111-8.
This study, based on data drawn from the responses of 18,323 males and 25,440 females to the 1988 National Health Interview Survey, a nationally representative, multistage probability sample of the United States, attempts to define more precisely the level of drinking at which the relationship between heart disease and alcohol consumption is a protective one. Its attempt at precision derives from (1) using drinking categories that represent various points within the range of moderate drinking (1-6 drinks) defined in the literature as protective; (2) adjusting for underreporting that commonly occurs in population surveys by using consumption at time of heaviest drinking; and (3) controlling for age, body mass, smoking, former drinker, and former smoker status, duration of drinking, and sociodemographic factors. It also examines whether the relationship derived from these levels conforms to the U-shaped curve that demonstrates the protective effect of moderate drinking when abstainers are not used as the reference group. Relative to infrequent drinkers (less than 1 drink per day), men report more heart disease at the level of more than five drinks per day. However, black men also report more heart disease, relative to infrequent drinkers, at the greater than two drinks per day level; and women report more heart disease at the level of more than two drinks per day at the time of their heaviest drinking. Former drinkers of both genders, considered as an independent variable in the regression analysis, were more likely to report having heart disease. Abstainers, light drinkers, and infrequent drinkers were not significantly different in their reports of heart disease. Our results are consistent with studies that suggest protection from heart disease occurs only at lower levels of drinking.
本研究的数据取自18323名男性和25440名女性对1988年美国国家健康访谈调查的回答,该调查是美国具有全国代表性的多阶段概率样本,旨在更精确地界定饮酒量水平,在这个水平上,心脏病与酒精消费之间的关系具有保护作用。其精确性源于:(1)使用代表文献中定义为具有保护作用的适度饮酒范围(1 - 6杯)内不同点的饮酒类别;(2)通过使用饮酒量最大时的消费量来调整人口调查中常见的漏报情况;(3)控制年龄、体重、吸烟、既往饮酒者和既往吸烟者状态、饮酒持续时间以及社会人口学因素。研究还考察了从这些饮酒量水平得出的关系是否符合U型曲线,该曲线表明在不将戒酒者作为参照组时适度饮酒的保护作用。相对于不常饮酒者(每天少于1杯),男性在每天饮酒超过5杯的水平上报告的心脏病更多。然而,相对于不常饮酒者,黑人男性在每天饮酒超过2杯的水平上也报告了更多心脏病;女性在饮酒量最大时每天饮酒超过2杯的水平上报告的心脏病更多。在回归分析中作为自变量考虑的两性既往饮酒者更有可能报告患有心脏病。戒酒者、轻度饮酒者和不常饮酒者在心脏病报告方面没有显著差异。我们的结果与一些研究一致,这些研究表明只有在较低饮酒量水平下才会出现对心脏病的保护作用。