fMLP类似物中第3位酰胺键的修饰可选择中性粒细胞功能。

Modifications of the amide bond at position 3 in fMLP analogs select neutrophil functions.

作者信息

Spisani S, Breveglieri A, Fabbri E, Vertuani G, Rizzuti O, Cavicchioni G

机构信息

University of Ferrara, Italy.

出版信息

Pept Res. 1996 Nov-Dec;9(6):279-82.

PMID:9048420

Abstract

The formylpeptides formyl-L-methionyl-L-leucyl-L-N-methylphenylalanine methyl ester 1, formyl-L-methionyl-L-leucyl-L-2-oxy-3-phenylpropionic acid methyl ester 2 and formyl-L-methionyl-L-leucyl-L-2-aminoxy-3-phenylpropionic acid methyl ester 3 were synthesized to investigate the role of the amide bond at position 3 in biological activity in human neutrophiles. Our results indicate that this amide bond is required for optimal chemotactic activity, but not for superoxide anion production.

摘要

合成了甲酰肽甲酰-L-甲硫氨酰-L-亮氨酰-L-N-甲基苯丙氨酸甲酯1、甲酰-L-甲硫氨酰-L-亮氨酰-L-2-氧代-3-苯丙酸甲酯2和甲酰-L-甲硫氨酰-L-亮氨酰-L-2-氨氧基-3-苯丙酸甲酯3，以研究3位酰胺键在人嗜中性粒细胞生物活性中的作用。我们的结果表明，这种酰胺键是最佳趋化活性所必需的，但不是超氧阴离子产生所必需的。