Jez J M, Flynn T G, Penning T M
Department of Biochemistry and Biophysics, University of Pennsylvania Medical School, Philadelphia 19104, USA.
Adv Exp Med Biol. 1997;414:579-600. doi: 10.1007/978-1-4615-5871-2_66.
As new members of the AKR superfamily are identified the need for a systematic and expandable nomenclature has risen, especially since some members of the superfamily have multiple names based on substrate specificity. We have proposed a nomenclature system for the AKR superfamily that is similar to the P450 system but based on amino acid sequence comparisons instead of nucleotide sequence comparisons. Our system uses percent amino acid identities to delineate families and subfamilies within the larger superfamily. Although there are not as many AKRs as P450s, having a flexible nomenclature system will allow for easy incorporation of new proteins into the superfamily.
随着AKR超家族新成员的不断发现，对系统且可扩展的命名法的需求日益凸显，尤其是鉴于该超家族的一些成员因底物特异性而有多个名称。我们提出了一种AKR超家族的命名系统，它类似于P450系统，但基于氨基酸序列比较而非核苷酸序列比较。我们的系统使用氨基酸序列一致性百分比来划分更大超家族中的家族和亚家族。尽管AKR的数量不如P450多，但拥有一个灵活的命名系统将便于新蛋白质纳入该超家族。
