与混合性冷球蛋白血症和丙型肝炎病毒感染相关的白细胞破碎性血管炎。

Leucocytoclastic vasculitis associated with mixed cryoglobulinaemia and hepatitis C virus infection.

作者信息

Abe Y, Tanaka Y, Takenaka M, Yoshida H, Yatsuhashi H, Yano M

机构信息

Department of Dermatology, Nagasaki University School of Medicine, Japan.

出版信息

Br J Dermatol. 1997 Feb;136(2):272-4.

PMID:9068749

Abstract

Mixed cryoglobulinaemia is frequently associated with chronic hepatitis. We report a patient with mixed cryoglobulinaemia, hepatitis C virus (HCV) infection and palpable purpura. The skin manifestations were diagnosed as leucocytoclastic vasculitis in view of both the clinical appearance and the histological findings. In this study, we demonstrated the presence of IgG-class anti-HCV-antibody, HCV-RNA and IgA-class rheumatoid factor in the cryoprecipitate. These results suggest that the cryoglobulinaemia in this case was caused by aggregation of an immune complex comprised of HCV and anti-HCV antibody with IgA-type-rheumatoid factor, and that this led to a cutaneous vasculitis.

摘要

混合性冷球蛋白血症常与慢性肝炎相关。我们报告一例患有混合性冷球蛋白血症、丙型肝炎病毒（HCV）感染和可触及性紫癜的患者。鉴于临床表现和组织学检查结果，皮肤表现被诊断为白细胞破碎性血管炎。在本研究中，我们在冷沉淀物中证实了IgG类抗HCV抗体、HCV-RNA和IgA类类风湿因子的存在。这些结果表明，该病例中的冷球蛋白血症是由HCV与抗HCV抗体以及IgA型类风湿因子组成的免疫复合物聚集所致，并导致了皮肤血管炎。