Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

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作者信息

Endo A, Tsujita Y, Kuroda M, Tanzawa K

出版信息

Eur J Biochem. 1977 Jul 1;77(1):31-6. doi: 10.1111/j.1432-1033.1977.tb11637.x.

DOI:10.1111/j.1432-1033.1977.tb11637.x

PMID:908337

Abstract

摘要

相似文献

Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

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Unsaturated fatty acyl-CoA inhibition of cholesterol synthesis in vitro.不饱和脂肪酰辅酶A对体外胆固醇合成的抑制作用。

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ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium.ML-236A、ML-236B和ML-236C，由桔青霉产生的新型胆固醇生物合成抑制剂。

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Cholesterol and mevalonic acid are independent requirements for the in vitro proliferation of human bone marrow granulocyte progenitor cells: studies using ML-236B.

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[Activities of 3-hydroxy-3-methylglutaryl-CoA reductase and acetyl-CoA carboxylase and rate of biosynthesis of mevalonic acid, squalene, sterols and fatty acids from [1-14C]acetyl-CoA and [2-14C]malonyl-CoA in rat liver: changes induced by daily rhythm].[大鼠肝脏中3-羟基-3-甲基戊二酰辅酶A还原酶和乙酰辅酶A羧化酶的活性以及由[1-¹⁴C]乙酰辅酶A和[2-¹⁴C]丙二酰辅酶A合成甲羟戊酸、角鲨烯、甾醇和脂肪酸的速率：昼夜节律引起的变化]

Biokhimiia. 1981 Jan;46(1):126-39.

[Activities of 3-hydroxyl-3-methylglutaryl-CoA reductase and acetyl-CoA carboxylase and the rate of mevalonic acid, squalene, sterol and fatty acid biosynthesis from [1-14C]acetyl-CoA and [2-14C]malonyl-CoA in rat liver: effects of Triton WR 1339, starvation and cholesterol diet].[大鼠肝脏中3-羟基-3-甲基戊二酰辅酶A还原酶和乙酰辅酶A羧化酶的活性以及[1-¹⁴C]乙酰辅酶A和[2-¹⁴C]丙二酰辅酶A生成甲羟戊酸、角鲨烯、固醇和脂肪酸的生物合成速率：曲拉通WR 1339、饥饿和胆固醇饮食的影响]

Biokhimiia. 1981 Feb;46(2):296-305.

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