新型正性肌力药物UK 14275对冠心病患者的心血管效应
Cardiovascular effects of a new inotropic agent, U. K. 14275, in patients with coronary heart disease.
作者信息
Hutton I, Hillis W S, Langhan C E, Conely J M, Lawrie T D
出版信息
Br J Clin Pharmacol. 1977 Oct;4(5):513-7. doi: 10.1111/j.1365-2125.1977.tb00778.x.
Abstract
1 The chronotropic and inotropic properties of U.K. 14275, a phosphodiesterase inhibitor were assessed in patients with coronary heart disease. 2 Left ventricular function was assessed in eight patients with acute myocardial infarction using the non-invasive measurement of systolic time intervals. 3 Twelve patients with angina pectoris were studied during diagnostic coronary arteriography. Left ventricular function was assessed using a high fidelity catheter tipped transducer in the left ventricle. 4 In both groups of patients U.K. 14275 infused intravenously in doses of 32, 64, 128 and 256 microgram kg-1 bodyweight min-1 enhanced the contractile state of the left ventricle without altering the heart rate.
摘要
- 对磷酸二酯酶抑制剂UK 14275的变时性和变力性特性在冠心病患者中进行了评估。2. 使用收缩期时间间期的非侵入性测量方法对8例急性心肌梗死患者的左心室功能进行了评估。3. 在诊断性冠状动脉造影期间对12例心绞痛患者进行了研究。使用置于左心室内的高保真导管顶端换能器对左心室功能进行了评估。4. 在两组患者中，以32、64、128和256微克/千克体重/分钟的剂量静脉输注UK 14275，可增强左心室的收缩状态，而不改变心率。
相似文献
1
Cardiovascular effects of a new inotropic agent, U. K. 14275, in patients with coronary heart disease.新型正性肌力药物UK 14275对冠心病患者的心血管效应
Br J Clin Pharmacol. 1977 Oct;4(5):513-7. doi: 10.1111/j.1365-2125.1977.tb00778.x.
2
Some aspects of the cardiovascular pharmacology of UK 14,275 in patients with coronary artery disease.UK 14,275在冠心病患者中的心血管药理学某些方面
Br J Clin Pharmacol. 1978 Jan;5(1):13-8. doi: 10.1111/j.1365-2125.1978.tb01592.x.
3
The inotropic effects of UK 14,275, a phosphodiesterase inhibitor, in man.磷酸二酯酶抑制剂 UK 14,275 对人体的变力作用。
Br J Clin Pharmacol. 1978 Jan;5(1):7-11. doi: 10.1111/j.1365-2125.1978.tb01591.x.
4
Cardiovascular effects of a new inotropic drug in dog and normal man.
Clin Pharmacol Ther. 1976 Jul;20(1):24-30. doi: 10.1002/cpt197620124.
5
Cardiovascular effects of UK 14,275: evaluation of a new phosphodiesterase inhibitor with inotropic properties in animals and human volunteers [proceedings].
Br J Clin Pharmacol. 1975 Aug;2(4):372P-373P.
6
Haemodynamic effects of prenalterol in patients with coronary heart disease.普瑞特罗对冠心病患者的血流动力学影响。
Br Heart J. 1980 Feb;43(2):134-7. doi: 10.1136/hrt.43.2.134.
7
Electrophysiological and haemodynamic effects of a new inotropic agent (UK14275) in the dog.
Clin Exp Pharmacol Physiol. 1979 Sep-Oct;6(5):585-9. doi: 10.1111/j.1440-1681.1979.tb00042.x.
8
[Alterations in left ventricular-arterial coupling and mechanical efficiency produced by remifentanil during cardiac anesthesia].[瑞芬太尼在心脏麻醉期间对左心室-动脉耦合及机械效率的影响]
Minerva Anestesiol. 2001 Mar;67(3):133-47.
9
Haemodynamic effects of Ro 13-6438, a new inotropic agent with vasodilating properties.
Drugs Exp Clin Res. 1986;12(5):381-4.
引用本文的文献
1
Haemodynamic effects of BM 10.188, a new orally active inotropic agent, in healthy volunteers.新型口服活性正性肌力药物BM 10.188对健康志愿者的血流动力学影响。
Br J Clin Pharmacol. 1982 Apr;13(4):529-32. doi: 10.1111/j.1365-2125.1982.tb01416.x.
2
Haemodynamic effects of prenalterol in patients with coronary heart disease.普瑞特罗对冠心病患者的血流动力学影响。
Br Heart J. 1980 Feb;43(2):134-7. doi: 10.1136/hrt.43.2.134.
本文引用的文献
1
Systolic time intervals in heart failure in man.人类心力衰竭时的收缩期时间间期
Circulation. 1968 Feb;37(2):149-59. doi: 10.1161/01.cir.37.2.149.
2
Evaluation of the pre-ejection period as an estimate of myocardial contractility in dogs.
Am J Cardiol. 1971 Apr;27(4):384-91. doi: 10.1016/0002-9149(71)90435-8.
3
Assessment of cardiac contractility. The relation between the rate of pressure rise and ventricular pressure during isovolumic systole.心脏收缩力评估。等容收缩期压力上升速率与心室压力之间的关系。
Circulation. 1971 Jul;44(1):47-58. doi: 10.1161/01.cir.44.1.47.
4
Factors influencing infarct size following experimental coronary artery occlusions.实验性冠状动脉闭塞后影响梗死面积的因素。
Circulation. 1971 Jan;43(1):67-82. doi: 10.1161/01.cir.43.1.67.
5
Inotropic changes in the left ventricle: the effect of changes in heart rate, aortic pressure and end-diastolic pressure.左心室的变力性变化：心率、主动脉压和舒张末期压力变化的影响。
J Physiol. 1970 Dec;211(2):359-87. doi: 10.1113/jphysiol.1970.sp009283.
6
The relationship of alterations in systolic time intervals to ejection fraction in patients with cardiac disease.心脏病患者收缩期时间间期改变与射血分数的关系。
Circulation. 1970 Sep;42(3):455-62. doi: 10.1161/01.cir.42.3.455.
7
Catheterization of the heart in man with use of a flow-directed balloon-tipped catheter.使用血流导向球囊导管对人体心脏进行导管插入术。
N Engl J Med. 1970 Aug 27;283(9):447-51. doi: 10.1056/NEJM197008272830902.
8
Effects of cardiac depression and of anesthesia on the myocardial action of a cardiac glycoside.心脏抑制和麻醉对强心苷心肌作用的影响。
J Clin Invest. 1971 Dec;50(12):2585-95. doi: 10.1172/JCI106759.
9
Coronary artery occlusion in the conscious dog. Effects of alterations in heart rate and arterial pressure on the degree of myocardial ischemia.
Circulation. 1972 Aug;46(2):323-32. doi: 10.1161/01.cir.46.2.323.
10
Effects of dobutamine on left ventricular performance, coronary dynamics, and distribution of cardiac output in conscious dogs.多巴酚丁胺对清醒犬左心室功能、冠状动脉动力学及心输出量分布的影响。
J Clin Invest. 1974 May;53(5):1265-73. doi: 10.1172/JCI107673.
Zotero 插件