α-黑素细胞刺激素（α-MSH）和促黑素细胞激素（MCH）可调节大鼠视前区的单胺能水平。

alpha-Melanocyte-stimulating hormone (alpha-MSH) and melanin-concentrating hormone (MCH) modify monoaminergic levels in the preoptic area of the rat.

作者信息

Gonzalez M I, Kalia V, Hole D R, Wilson C A

机构信息

Department of Obstetrics and Gynaecology, St. George's Hospital Medical School, London, UK.

出版信息

Peptides. 1997;18(3):387-92. doi: 10.1016/s0196-9781(96)00337-3.

DOI:10.1016/s0196-9781(96)00337-3

PMID:9145425

Abstract

The effect of perfusion of melanin-concentrating hormone (MCH) or alpha-melanocyte-stimulating hormone (alpha-MSH) (100 ng/microliter) in the ventromedial nucleus (VMN) or medial preoptic area (MPOA) on monoaminergic levels of female rats was measured using microdialysis and HPLC-electrochemical detection. In the MPOA, alpha-MSH raised 5-HIAA concentration, whereas MCH reduced both 5-HT and 5-HIAA. Neither peptide had any effect in the VMN. The opposite effects of the peptides on the serotonergic system might be responsible for their antagonistic or opposite actions previously reported on several CNS functions. Dopamine may mediate the similar effects of the two peptides, because alpha-MSH inhibits dopaminergic release in the MPOA (but not VMN) and MCH tends to follow the same pattern.

摘要

使用微透析和高效液相色谱 - 电化学检测法，测定向雌性大鼠腹内侧核（VMN）或内侧视前区（MPOA）灌注黑色素浓缩激素（MCH）或α - 黑素细胞刺激激素（α - MSH）（100纳克/微升）对单胺能水平的影响。在MPOA中，α - MSH提高了5 - HIAA浓度，而MCH降低了5 - HT和5 - HIAA。两种肽在VMN中均无任何作用。这些肽对血清素能系统的相反作用可能是它们先前在几种中枢神经系统功能上所报道的拮抗或相反作用的原因。多巴胺可能介导了这两种肽的相似作用，因为α - MSH抑制MPOA（而非VMN）中的多巴胺能释放，且MCH倾向于遵循相同模式。