丁胺卡那霉素对裸鼠和米色小鼠体内鸟分枝杆菌复合群的比较活性
Comparative activities of amikacin against Mycobacterium avium complex in nude and beige mice.
作者信息
Lounis N, Ji B, Truffot-Pernot C, Grosset J
机构信息
Bacteriologie et Virologie, Faculte de Medecine, Pitie-Salpetriere, Paris, France.
出版信息
Antimicrob Agents Chemother. 1997 May;41(5):1168-9. doi: 10.1128/AAC.41.5.1168.
Abstract
After 4 weeks of treatment, clarithromycin (CLAR) and amikacin showed similar antimicrobial activities against the Mycobacterium avium complex in mice. There was a difference, however, in the effectiveness of the drugs in different types of mice: both drugs displayed bactericidal effects in beige mice but only bacteriostatic effects in nude mice. Because the effectiveness of CLAR is less in nude mice than in beige mice, the predictive value of the nude mouse model for the efficacy of chemotherapy is less than that of the beige mouse model.
摘要
治疗4周后，克拉霉素（CLAR）和阿米卡星对小鼠体内鸟分枝杆菌复合群显示出相似的抗菌活性。然而，这两种药物在不同类型小鼠中的有效性存在差异：两种药物在米色小鼠中均表现出杀菌作用，但在裸鼠中仅表现出抑菌作用。由于CLAR在裸鼠中的有效性低于在米色小鼠中的有效性，裸鼠模型对化疗疗效的预测价值低于米色小鼠模型。
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