造血生长因子
Haemopoietic growth factors.
作者信息
Ketley N J, Newland A C
机构信息
Department of Haematology, London Hospital Medical College, UK.
出版信息
Postgrad Med J. 1997 Apr;73(858):215-21. doi: 10.1136/pgmj.73.858.215.
Haemopoietic growth factors are involved in the production of the various blood cells from progenitors in the bone marrow, making them useful in a range of clinical situations. The genes for several of them have been cloned and their production engineered by recombinant technology, making them widely available. Myeloid growth factors are used to support patients in the aftermath of chemotherapy and bone marrow transplantation and have potential application in the treatment of infectious diseases. Erythropoietin is widely used for patients with anaemia due to failure of marrow production, having established its effectiveness in chronic renal failure. Thrombopoietin has recently been described and may provide a means to alleviate thrombocytopenia. Current indications and areas of recent reappraisal are addressed in this review.
造血生长因子参与骨髓中祖细胞产生各种血细胞的过程，使其在一系列临床情况下都很有用。其中几种因子的基因已被克隆，并通过重组技术进行生产，从而使其广泛可得。髓系生长因子用于在化疗和骨髓移植后支持患者，并在传染病治疗中具有潜在应用。促红细胞生成素广泛用于因骨髓生成衰竭而贫血的患者，已在慢性肾衰竭中证实其有效性。血小板生成素最近已被描述，可能提供一种缓解血小板减少症的方法。本综述探讨了当前的适应证和近期重新评估的领域。
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