乙醇对大鼠肝脏和大脑中多巴胺代谢的影响。

The effects of ethanol on dopamine metabolism in rat liver and brain.

作者信息

Tank A W, Weiner H

出版信息

Adv Exp Med Biol. 1977;85A:473-83. doi: 10.1007/978-1-4899-5181-6_29.

PMID:920492

Abstract

Levels of dopamine metabolites are drastically altered in the presence of ethanol in liver slices, however no change in brain metabolism of dopamine is observed in a conscious animal which has been administered ethanol. Though THP can be formed in the cell during the metabolism of dopamine, increasing DOPAL levels does not cause an increase in THP formation. Thus if this compound is important in the overall alcohol problem more subtle ways of looking at its formation in individual synaptic regions will have to be developed in order to determine if ethanol will alter its level.

摘要

在肝切片中存在乙醇的情况下，多巴胺代谢物水平会发生显著变化，然而，在给予乙醇的清醒动物中，未观察到多巴胺脑代谢的变化。虽然在多巴胺代谢过程中细胞内可形成四氢嘧啶，但增加3,4-二羟基苯乙醛（DOPAL）水平并不会导致四氢嘧啶形成增加。因此，如果这种化合物在整体酒精问题中很重要，那么就必须开发更精细的方法来观察其在各个突触区域的形成，以确定乙醇是否会改变其水平。