[Patterns and the role of changes in the sympathetic and parasympathetic regulation of the heart in local ischemia and reperfusion].

Modelling of transient coronary insufficiency on 480 conscious and unconscious non-inbred albino mate rats during 10-, 40-, or 120-min coronary occlusion, followed by 40-60-min myocardial reperfusion revealed characteristic changes in the sympathetic and parasympathetic mechanisms of cardiac regulation. According to the extent and duration, 3 phenomena were identified, which were of mainly adaptive or pathogenic significance. These included: 1) replacement of the domination of sympathetic influences on the heart by the predomination of parasympathetic effects; 2) development of hormonal and neuromediator dissociation of catecholamine levels in the heart; 3) regulation-restricted cardiac participation in systemic hemodynamic responses. The predomination of adaptive effects of the above phenomena caused a reduction in the ischemic and reperfusion alteration of the heart and potentiated its reparative processes. With progression and more prolonged duration of these phenomena there is an additional myocardial regulatory alteration.