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[未成熟大鼠颅脑创伤动态过程中脑内生物能量过程的状态]

[Status of bioenergetic processes in brain of immature rats during the dynamics of cranio-cerebral trauma].

作者信息

Novikov V E, Kovaleva L A, Kozlov N B, Sharov A N

出版信息

Vopr Med Khim. 1996 Oct-Dec;42(4):309-11.

PMID:9254516
Abstract

In one month's old rats open cranio-cerebral injury was modelled. During the post-traumatic period the state of bioenergetic processes in brain tissues was studied in dynamics. Disturbance of oxidative phosphorylation in cerebral mitochondria and depression of membranes ATPase activity was revealed. This changes were most expressed in 1-4 days after the injury. Recovery of the impaired bioenergetic processes in post-traumatic period in one month's old rats is slower than in adult.

摘要

对1月龄大鼠进行开放性颅脑损伤建模。在创伤后时期,动态研究脑组织中生物能量过程的状态。发现脑线粒体中氧化磷酸化紊乱以及膜ATP酶活性降低。这些变化在损伤后1 - 4天最为明显。1月龄大鼠创伤后受损生物能量过程的恢复比成年大鼠慢。

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