一名未感染艾滋病毒儿童的马尔尼菲青霉感染

Penicillium marneffei infection in a non-HIV infected child.

作者信息

Kwan E Y, Lau Y L, Yuen K Y, Jones B M, Low L C

机构信息

Department of Paediatrics, University of Hong Kong.

出版信息

J Paediatr Child Health. 1997 Jun;33(3):267-71. doi: 10.1111/j.1440-1754.1997.tb01596.x.

DOI:10.1111/j.1440-1754.1997.tb01596.x

PMID:9259309

Abstract

We report a case of Penicillium marneffei infection in a previously healthy 3.5 years-old Chinese boy and review the literature. The details of the case are described with emphasis on his immune function and treatment outcome. This boy had transient immunodeficiency involving phagocytic and NK cells due to P. marneffei infection which resolved after treatment with gamma interferon and amphotericin B. A prolonged course of fluconazole of 1 year was successful in preventing relapse. Gamma interferon, amphotericin B and a prolonged course of fluconazole may be useful in the treatment of life-threatening infection by P. marneffei.

摘要

我们报告一例3.5岁健康中国男孩感染马尔尼菲青霉的病例，并对相关文献进行综述。详细描述该病例，重点关注其免疫功能和治疗结果。该男孩因马尔尼菲青霉感染出现涉及吞噬细胞和自然杀伤细胞的短暂免疫缺陷，经γ干扰素和两性霉素B治疗后得以缓解。为期1年的氟康唑长疗程治疗成功预防了复发。γ干扰素、两性霉素B以及氟康唑长疗程治疗可能对治疗马尔尼菲青霉所致的危及生命的感染有效。