用于光损伤皮肤的维甲酸润肤霜：48周多中心双盲研究结果
Tretinoin emollient cream for photodamaged skin: results of 48-week, multicenter, double-blind studies.
作者信息
Olsen E A, Katz H I, Levine N, Nigra T P, Pochi P E, Savin R C, Shupack J, Weinstein G D, Lufrano L, Perry B H
机构信息
Dermatopharmacology Study Center, Duke University Medical Center, Durham, NC 27710, USA.
出版信息
J Am Acad Dermatol. 1997 Aug;37(2 Pt 1):217-26. doi: 10.1016/s0190-9622(97)80128-4.
BACKGROUND
The ability of topical tretinoin to improve certain signs of skin photodamage has been shown previously.
OBJECTIVE
Our purpose was to assess the effectiveness of tretinoin emollient cream in maintaining or further improving photodamaged skin during extended use.
METHODS
Photodamaged subjects who completed 24 weeks of once-daily use of tretinoin emollient cream 0.05% (n = 149) or 0.01% (n = 149) continued to use the same strength formulation in a 24-week double-blind extension.
RESULTS
Maintenance of improvement or continued reduction in signs of photodamage was noted in both investigators' and subjects' evaluations of the 0.05% and 0.01% preparations; these results were confirmed by skin replica analyses. Cutaneous side effects were less common during the extension study than during the first 24 weeks of therapy.
CONCLUSION
Both strengths of tretinoin emollient cream (0.05% and 0.01%) appeared safe and effective in the treatment of photodamaged skin during a 48-week treatment period.
背景
先前已证实局部外用维甲酸可改善皮肤光损伤的某些体征。
目的
我们的目的是评估维甲酸润肤霜在长期使用过程中维持或进一步改善光损伤皮肤的有效性。
方法
完成24周每日一次使用0.05%（n = 149）或0.01%（n = 149）维甲酸润肤霜的光损伤受试者，在一项为期24周的双盲延长期中继续使用相同强度的制剂。
结果
在研究者和受试者对0.05%和0.01%制剂的评估中，均注意到光损伤体征维持改善或持续减轻；这些结果通过皮肤复制品分析得到证实。在延长期研究中，皮肤副作用比治疗的前24周少见。
结论
在48周的治疗期内，两种强度的维甲酸润肤霜（0.05%和0.01%）在治疗光损伤皮肤方面似乎都是安全有效的。
Zotero 插件