职业性接触粉尘：炎症与缺血性心脏病。
Occupational exposure to dust: inflammation and ischaemic heart disease.
作者信息
Sjögren B
机构信息
Department of Occupational Health, Swedish National Institute for Working Life, Solna, Sweden.
出版信息
Occup Environ Med. 1997 Jul;54(7):466-9. doi: 10.1136/oem.54.7.466.
Abstract
OBJECTIVES
To review the possible association between occupational exposure to dust and ischaemic heart disease (IHD).
METHODS
A literature search was performed of relevant studies regarding IHD in specific exposures to dust. The chosen exposures were arsenic, asbestos, beryllium, lead, polycyclic aromatic hydrocarbons, and quartz. The chosen occupations were farmers, paper and paper pulp workers, sawyers, and welders.
DISCUSSION
A theory was launched in 1995 that urban particulate air pollution may provoke alveolar inflammation, with release of mediators capable of increasing blood coagulability in susceptible people and cause cardiovascular deaths. The present review expands this hypothesis and links occupational exposure to inhaled particles with the occurrence of ischaemic heart disease.
CONCLUSION
This hypothesis should be tested by comparing the concentrations of fibrinogen in workers exposed and nonexposed to particles with control for other possible confounders such as smoking habits.
摘要
目的
回顾职业性接触粉尘与缺血性心脏病（IHD）之间可能存在的关联。
方法
对特定粉尘暴露情况下有关缺血性心脏病的相关研究进行文献检索。选定的暴露物为砷、石棉、铍、铅、多环芳烃和石英。选定的职业为农民、造纸及纸浆工人、锯木工和焊工。
讨论
1995年提出一种理论，即城市颗粒空气污染可能引发肺泡炎症，释放出能够增加易感人群血液凝固性并导致心血管死亡的介质。本综述扩展了这一假说，并将职业性接触吸入颗粒物与缺血性心脏病的发生联系起来。
结论
应通过比较接触和未接触颗粒物的工人中纤维蛋白原的浓度，并控制其他可能的混杂因素（如吸烟习惯）来验证这一假说。
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