头颈部肿瘤DNA检测的作用。

Role of DNA measurements of head and neck tumors.

作者信息

Milroy C M, Ferlito A, Devaney K O, Rinaldo A

机构信息

Department of Forensic Pathology, University of Sheffield, England.

出版信息

Ann Otol Rhinol Laryngol. 1997 Sep;106(9):801-4. doi: 10.1177/000348949710600919.

DOI:10.1177/000348949710600919

PMID:9302918

Abstract

The measurement of DNA ploidy has been used as a tool to try to determine the prognosis of many neoplasms. DNA ploidy can be determined by flow cytometry or image analysis of a tumor. In squamous carcinomas of the head and neck, a poorer prognosis has been associated with nondiploid tumors. Similar results have been obtained from studies of salivary gland neoplasms. The role of DNA ploidy as a provider of independent information has yet to be determined. With rarer head and neck tumors, measurement of tumor ploidy has yet to be established as a valuable adjunct to routine light microscopic study.

摘要

DNA倍体的测量已被用作一种试图确定许多肿瘤预后的工具。DNA倍体可通过肿瘤的流式细胞术或图像分析来确定。在头颈部鳞状细胞癌中，非二倍体肿瘤的预后较差。唾液腺肿瘤的研究也得到了类似的结果。DNA倍体作为独立信息提供者的作用尚未确定。对于较罕见的头颈部肿瘤，肿瘤倍体的测量尚未被确立为常规光学显微镜研究的有价值辅助手段。