费拉拉地区地中海贫血的分离分析。
Segregation analysis of thalassemia in Ferrara.
作者信息
Papi C, Prampolini B, Vullo C, Barra I
出版信息
Am J Hum Genet. 1977 Nov;29(6):627-34.
Abstract
Segregation analysis of 996 families in which the gene for beta-thalassemia was segregating showed no distortion of expected Mendelian ratios. No appreciable frequency of sporadic cases was detected. It was suggested that segregation distortion is not a mechanism which contributes to the maintenance of polymorphism in the beta-thalassemia system in the population of the Ferrara area.
摘要
对996个β地中海贫血基因发生分离的家族进行的分离分析显示，预期的孟德尔比率未出现偏差。未检测到明显的散发病例频率。有人认为，分离畸变并非费拉拉地区人群β地中海贫血系统中维持多态性的一种机制。
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