Potthoff P, Biefang S, Bellach B, Buschmann-Steinhage R
Infratest Epidemiologie und Gesundheitsforschung, München.
Gesundheitswesen. 1997 Jun;59(6):362-71.
The principle "priority of rehabilitation over early retirement" might be realised by a screening by which employees in need of rehabilitation are detected in time and rehabilitation measures are purposively started. With the "Index of Rehabilitation Need" we continued our efforts to develop an applicable screening tool on an epidemiological basis. To this end (1) longitudinal data were established by repeating an epidemiological survey of a population sample in the Nordenham/Brake region (T0 = 1975/76, T1 = 1992/93); (2) T0-variables were identified which correlated significantly with the events of early retirement and/or rehabilitation in the period of T0 to T1 (98 cases of early retirement/357 controls; 127 cases of rehabilitation/200 controls; 185 cases of early retirement of rehabilitation/270 controls) using bivariate and multivariate regression analysis; (3) significant T0-variables were used to construct a questionnaire index (based on self assessment of symptoms/complaints, consumption of medicaments, smoking, and work load--16 items), a medical examination index (based on clinical/laboratory findings and medical diagnoses--10 items), and an overall index (sum of both indices--26 items); (4) the index values were calculated for cases of early retirement of rehabilitation and controls of the cohort (185/270), for each index significant differences between cases and controls tested, and the screening characteristics of the overall index analysed; (5) possible reasons for incorrect classifications were examined using a subsample of cases and controls (n = 96/78), for which additional data on medical and work history, stressful life events, and attitudes towards rehabilitation had been collected. All indices showed significant differences between cases of early retirement or rehabilitation and controls. These differences proved to be stronger with the questionnaire and overall indices (p < .0000 each) than with the medical examination index (p < .0006). The overall index did not detect 18% of the cases in need of rehabilitation (false negatives). The proportion of the false positives was 14%; sensitivity and specificity amounted to 57% and 76%. The analysis of the subsample revealed only two possible and plausible reasons for incorrect classifications: the time span between the first survey and the year of early retirement as well as injuries. The index detected cases of early retirement or rehabilitation more easily where the time span between T0 and the year of early retirement was shorter. The index cannot detect cases of early retirement and rehabilitation caused by injuries between T0 and T1, since it is based on chronic disorders and stresses to be the reason for both events. With respect to the sensitivity and specificity of the index the relatively long prediction period needs to be taken into consideration--between T0 and the time of the events there could have been a period of up to 17 years. However, the objective of a screening is not to predict the long-term outcome but to preselect persons who are likely to need rehabilitation and should be invited to a socio-medical examination in order to clarify their rehabilitation need and to start appropriate rehabilitation measures. The chance to detect true positive candidates and to exclude false negative candidates is essentially higher when the measurement of the predictors and the examination are carried out at the same time as has been shown in a former study. With regard to further proceedings we suggest to apply the index in a screening and to investigate the cost effectiveness and other aspects of the screening in a demonstration project.
“康复优先于提前退休”这一原则可通过一项筛查得以实现,即通过该筛查及时发现需要康复的员工,并针对性地启动康复措施。我们借助“康复需求指数”继续努力在流行病学基础上开发一种适用的筛查工具。为此:(1) 通过重复对北德讷姆/布拉克地区的人群样本进行流行病学调查(T0 = 1975/76,T1 = 1992/93)建立纵向数据;(2) 利用双变量和多变量回归分析确定在T0至T1期间与提前退休和/或康复事件显著相关的T0变量(98例提前退休/357例对照;127例康复/200例对照;185例提前退休或康复/270例对照);(3) 使用显著的T0变量构建一份问卷指数(基于对症状/不适、药物消费、吸烟和工作量的自我评估——16项)、一份医学检查指数(基于临床/实验室检查结果和医学诊断——10项)以及一份综合指数(两个指数之和——26项);(4) 为提前退休或康复的病例以及该队列的对照(185/270)计算指数值,检验病例与对照之间每个指数的显著差异,并分析综合指数的筛查特征;(5) 利用病例和对照的一个子样本(n = 96/78)检查错误分类的可能原因,为此收集了关于医疗和工作史、应激性生活事件以及对康复态度的额外数据。所有指数在提前退休或康复的病例与对照之间均显示出显著差异。这些差异在问卷指数和综合指数中(均为p <.0000)比在医学检查指数中(p <.0006)更为明显。综合指数未检测出18%需要康复的病例(假阴性)。假阳性比例为14%;敏感性和特异性分别为57%和76%。对子样本的分析仅揭示了错误分类的两个可能且合理的原因:首次调查与提前退休年份之间的时间跨度以及受伤情况。该指数在T0与提前退休年份之间的时间跨度较短时更容易检测出提前退休或康复的病例。该指数无法检测出T0与T1之间由受伤导致的提前退休和康复病例,因为它基于慢性疾病和压力作为这两种情况的原因。考虑到指数的敏感性和特异性,需要考虑相对较长的预测期——在T0与事件发生时间之间可能长达17年。然而,筛查的目的不是预测长期结果,而是预选可能需要康复的人员,并应邀请他们进行社会医学检查,以明确其康复需求并启动适当的康复措施。正如之前一项研究所表明的,当预测指标的测量与检查同时进行时,检测出真正阳性候选者并排除假阴性候选者的机会本质上更高。关于进一步的程序,我们建议在筛查中应用该指数,并在一个示范项目中研究筛查的成本效益和其他方面。