将土木香内酯仿生环化转化为来自马拉加矢车菊的具有细胞毒性的桉烷内酯马拉西他内酯。
Biomimetic cyclization of cnicin to malacitanolide, a cytotoxic eudesmanolide from Centaurea malacitana.
作者信息
Barrero A F, Oltra J E, Morales V, Alvarez M, Rodríguez-García I
机构信息
Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Granada, Spain.
出版信息
J Nat Prod. 1997 Oct;60(10):1034-5. doi: 10.1021/np970040p.
PMID:9358646
Abstract
Malacitanolide (2), a new eudesmanolide isolated from the aerial parts of Centaurea malacitana, was characterized spectroscopically. The synthesis of 2 from cnicin (1), via the epoxide 3, confirmed the structure and stereochemistry of malacitanolide, as well as its biogenetic relationship with 1. Cytotoxic activity values for 2 are significantly higher than for 1.
摘要
马拉西他内酯（2）是从马拉西坦矢车菊地上部分分离得到的一种新的桉烷型倍半萜内酯，通过光谱进行了表征。由菊苣内酯（1）经环氧化物3合成2，证实了马拉西他内酯的结构和立体化学，以及它与1的生源关系。2的细胞毒性活性值明显高于1。
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