壶孢菌素，一种从壶孢霉HKI-0053中分离得到的新型肽菌素类抗生素，对小鼠具有抗精神病活性。

Ampullosporin, a new peptaibol-type antibiotic from Sepedonium ampullosporum HKI-0053 with neuroleptic activity in mice.

作者信息

Ritzau M, Heinze S, Dornberger K, Berg A, Fleck W, Schlegel B, Härtl A, Gräfe U

机构信息

Hans-Knöll-Institute of Natural Products Research, Jena, Germany.

出版信息

J Antibiot (Tokyo). 1997 Sep;50(9):722-8. doi: 10.7164/antibiotics.50.722.

DOI:10.7164/antibiotics.50.722

PMID:9360615

Abstract

Ampullosporin (I; Ac-Trp-Ala-Aib-Aib-Leu-Aib-Gln-Aib-Aib-Aib-Gln-Leu-Aib-Gln-Leuol) was isolated from the mycelium of Sepedonium ampullosporum as a new 15-membered peptaibol-type antibiotic. The structure was determined by mass spectrometric and two-dimensional NMR experiments. Ampullosporin displays narrow-spectrum antibacterial and antifungal activity, induces pigment formation by Phoma destructiva, causes hypothermia and decreased spontaneous locomotor activity in mice in dosages > 1 mg/kg.

摘要

壶孢菌素（I；Ac-Trp-Ala-Aib-Aib-Leu-Aib-Gln-Aib-Aib-Aib-Gln-Leu-Aib-Gln-Leuol）是从壶孢菌的菌丝体中分离得到的一种新型15元肽菌素类抗生素。其结构通过质谱和二维核磁共振实验确定。壶孢菌素具有窄谱抗菌和抗真菌活性，能诱导毁灭茎点霉形成色素，在剂量>1mg/kg时可导致小鼠体温过低和自发运动活动减少。