Edelman J D, Bavaria J, Kaiser L R, Litzky L A, Palevsky H I, Kotloff R M
Department of Medicine, University of Pennsylvania Medical Center, Philadelphia 19104, USA.
Chest. 1997 Oct;112(4):1140-4. doi: 10.1378/chest.112.4.1140.
Pulmonary alveolar microlithiasis (PAM) is characterized by deposition of calcium phosphate within the alveolar airspaces. There is currently no effective medical therapy and affected individuals may progress to end-stage lung disease requiring transplantation. Two patients with PAM underwent bilateral sequential lung transplantation. This study reviews the clinical manifestations of PAM and discusses the particular difficulties that may be encountered in the use of lung transplantation as treatment for this uncommon disease. Also addressed is the question of recurrence in the allograft.
肺泡微石症（PAM）的特征是磷酸钙在肺泡气腔内沉积。目前尚无有效的药物治疗方法，患者可能会进展为需要进行移植的终末期肺病。两名肺泡微石症患者接受了双侧序贯肺移植。本研究回顾了肺泡微石症的临床表现，并讨论了将肺移植用作这种罕见疾病治疗方法时可能遇到的特殊困难。还讨论了同种异体移植中复发的问题。
